Background: To study the clinical and haematological profile of patients admitted with P. vivax mono-infection at Azeezia Medical College, Kollam.

Materials and Methods: This is a prospective cohort study was done from April 2022 to March 2023 on 200 patients admitted to Azeezia Medical College, Kollam. The subjects selected were positive for P. vivax by peripheral smear and negative for HRP-2 test. The patient selection was based on inclusion and exclusion criteria.

Result: In this study group of 200 patients, 141 were males and 59 were females. Most subjects were in the second and third decades of life. The mean age of subjects was 37.32 years. Fever was seen in all patients. Other clinical symptoms were headache (68%), jaundice (28.5%), vomiting (27.5%), body pain (17.5%), pain abdomen (9%), diarrhoea (6.5%) and bleeding manifestations (2%) in the order of occurrence. Thrombocytopenia was observed in 187 (93.5%) patients. Thirty three patients (6.5%) had severe thrombocytopenia. Anaemia was seen in 59 (29.5%) patients. Leucocytosis and leucopenia were seen in 20 and 26 cases respectively. Complications observed were acute kidney injury (AKI), elevated transaminases, adult respiratory distress syndrome (ARDS) and cerebral malaria 2.5%, 2.5%, 1% and 1% respectively.

Conclusion: The clinical spectrum of P. vivax mono infection varied from fever to bleeding manifestations. In this study, the most common symptoms were fever, headache, jaundice and vomiting. The commonest haematological variations observed were anaemia and thrombocytopenia.