Menu
  • Publish Your Research/Review Articles in our High Quality Journal for just USD $99*+Taxes( *T&C Apply)

Research Article

Role of Ascorbic Acid in Ameliorating Dextromethorphan-Induced Testicular Toxicity in Sprague-Dawley Rat Model

Oluwaseye Adebajo*, Perpetual Adebajo, Honor Ojo, Oluwatobiloba Ayoade, Princess Ulasi, Michael Olajide and Lois Ajeseni

Corresponding Author: Oluwaseye Adebajo, Anatomy Programme, College of Health Sciences, Bowen University, Iwo campus, Iwo, Osun state, Nigeria.

Received: May 08, 2024 ;    Revised: May 31, 2024 ;    Accepted: June 03, 2024 ;   Available Online: June 05, 2024

Citation: Adebajo O, Adebajo P, Ojo H, Ayoade O, Ulasi P, et al. (2024) A Role of Ascorbic Acid in Ameliorating Dextromethorphan-Induced Testicular Toxicity in Sprague-Dawley Rat Model. J Pharm Sci Drug Discov, 3(1): 1-8.

Copyrights: ©2024 Adebajo O, Adebajo P, Ojo H, Ayoade O, Ulasi P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Share Your Publication :

Views & Citations

952

Likes & Shares

0


Global Views

  • Abstract
  • Full Text
  • Images
  • Tables
  • References
  • PDF
  • Supplementary Files

Background: Dextromethorphan (DM) is a cough suppressant, commonly abused among young adults. Ascorbic acid has been proved to have great ameliorative properties on the toxicity in the testes. Evaluating the effect of ascorbic acid on the testes of Sprague-Dawley rats exposed to dextromethorphan-induced testicular toxicity.

Objective: To evaluate the ameliorative potential of ascorbic acid on the seminal parameters (counts, motility, morphology) in Dextromethorphan-induced testicular toxicity in Sprague-Dawley rats.

Methods: Forty ats were used and divided into four groups (n=10) as follows: Group 1 received 0 mg/kg, Group 2-4: 20,40,80mg/kg of DM respectively for four weeks. Upon completion, 5 rats were randomly selected and euthanized from each group and the remaining animals received 100 mg/kg of Ascorbic acid for a period of four weeks. Upon completion, the rats were randomly picked and euthanized for histology on the testes, hormonal milieu parameter and oxidative stress.

Results: Dextromethorphan decreased rat testicular weight, inhibited spermatogenesis, decreased reproductive hormones and also induced oxidative stress which may cause a decline in reproductive function. Administration of Ascorbic Acid was able to restore reproductive functions.

Conclusion: The results showed that Dextromethorphan could affect reproduction function that can culminate into male infertility, amelioration was recorded upon administration of Ascorbic Acid as an antioxidant.

Keywords: Dextromethorphan, Ascorbic acid, Semen parameters, Oxidative stress

Mpgyi